Show:

All Document Video
 
MDR-PK Studies

14 Jul 2015

Multidrug-resistant tuberculosis (MDR-TB; i.e. resistance to both rifampicin and isoniazid) is an emerging global epidemic, and requires treatment with second-line anti-TB medications. Although second-line anti-TB drugs are routinely given and recommended in children, there is limited information available to inform the accurate dosing in young and in HIV-infected children, who may have altered drug metabolism and drug-drug interactions.

Read More
Operational Research Assistance Project - ORAP

14 Jul 2015

Operational research (OR) is increasingly recognised as an essential component of health programmes. OR, defined as the “the search for knowledge on interventions, strategies, or tools that can enhance the quality, effectiveness, or coverage of programmes in which the research is being done” has special relevance in South Africa

Read More
The MVA85A Vaccine Trial

14 Jul 2015

We have completed enrolment on this study of a new TB vaccine, MVA85A, using a reverse prime boosting strategy, in HIV-exposed infants. We enrolled 144 babies born to HIV positive mothers.

Read More
Line Probe Assay - LPA

14 Jul 2015

The World Health Organisation (WHO) has identified five priorities to accelerate progress towards achieving the 2015 United Nation’s Millennium Development Goals for tuberculosis (TB). The first of these is to “reach the missed cases”, the estimated 2.9 million TB cases that are not diagnosed or reported in national notification systems.

Read More
 
The diagnostics platform within the DTTC paediatric research programme

14 Jul 2015

The diagnosis of TB in young children can be challenging and is seldom bacteriologically confirmed, as young children, who are most affected by the disease, cannot produce sputum spontaneously. In order to obtain adequate specimens for lab testing, relatively invasive methods are used.

Read More
Adolescent Qualitative Study

14 Jul 2015

Adolescents experience a large burden of tuberculosis (TB) disease including multidrug-resistant (MDR)-TB. However, they are often excluded from research, despite their biological and social characteristics needs for inclusion in research. The views of adolescents towards participation in research have been poorly described to date, particularly in resource-limited settings.

Read More
The PopART trial

14 Jul 2015

The HPTN 071 or PopART trial is a cluster-randomized trial which aims to determine the impact of two community-level combination prevention packages, both of which include universal HIV testing and intensified provision of HIV/ART care, on population-level HIV incidence.

Read More
Community AIDS Prevention Project - COMAPP

14 Jul 2015

In South Africa, 12% of the population (6.4 million) are living with HIV. The AIDS epidemic is generalised with primarily heterosexual transmission. Knowing one’s HIV status is essential, making HIV counselling and testing (HCT), a vital component of HIV care and prevention.

Read More