Childhood TB


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MDR-PK Studies

14 Jul 2015

Multidrug-resistant tuberculosis (MDR-TB; i.e. resistance to both rifampicin and isoniazid) is an emerging global epidemic, and requires treatment with second-line anti-TB medications. Although second-line anti-TB drugs are routinely given and recommended in children, there is limited information available to inform the accurate dosing in young and in HIV-infected children, who may have altered drug metabolism and drug-drug interactions.

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The MVA85A Vaccine Trial

14 Jul 2015

We have completed enrolment on this study of a new TB vaccine, MVA85A, using a reverse prime boosting strategy, in HIV-exposed infants. We enrolled 144 babies born to HIV positive mothers.

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The diagnostics platform within the DTTC paediatric research programme

14 Jul 2015

The diagnosis of TB in young children can be challenging and is seldom bacteriologically confirmed, as young children, who are most affected by the disease, cannot produce sputum spontaneously. In order to obtain adequate specimens for lab testing, relatively invasive methods are used.

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Adolescent Qualitative Study

14 Jul 2015

Adolescents experience a large burden of tuberculosis (TB) disease including multidrug-resistant (MDR)-TB. However, they are often excluded from research, despite their biological and social characteristics needs for inclusion in research. The views of adolescents towards participation in research have been poorly described to date, particularly in resource-limited settings.

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