Group leader: Dr Balindiwe Sishi

Research Focus:
The research group investigates the side effects of chemotherapy, particularly doxorubicin, on the heart. Cardiotoxicity, defined as a range of adverse effects on the heart’s function induced by therapeutic molecules, is now considered one of the most important consequences  of  chemotherapy,  leading  to  an  increase  in  morbidity  and  mortality  of  cancer survivors.

Mechanisms:

Oxidative stress

Mitophagy

Autophagy

Mitochondrial health/respiration

Associated signalling pathways