Publications

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Heuts, J. P. A.; Klumperman, B. Composition Drift in Radical Copolymerization. European Polymer Journal 2024, 215. https://doi.org/10.1016/j.eurpolymj.2024.113215.
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Autzen, A. A. A.; Beuermann, S.; Drache, M.; Fellows, C. M.; Harrisson, S.; van Herk, A. M.; Hutchinson, R. A.; Kajiwara, A.; Keddie, D. J.; Klumperman, B.; Russell, G. T. IUPAC Recommended Experimental Methods and Data Evaluation Procedures for the Determination of Radical Copolymerization Reactivity Ratios from Composition Data. Polym. Chem. 2024, 15 (18), 1851–1861. https://doi.org/10.1039/D4PY00270A.
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Ayub, H.; Murray, R. J.; Kuyler, G. C.; Napier-Khwaja, F.; Gunner, J.; Dafforn, T. R.; Klumperman, B.; Poyner, D. R.; Wheatley, M. GPCRs in the Round: SMA-like Copolymers and SMALPs as a Platform for Investigating GPCRs. Archives of Biochemistry and Biophysics 2024, 754, 109946. https://doi.org/https://doi.org/10.1016/j.abb.2024.109946.
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Motloung, B.; Pfukwa, R.; Klumperman, B. Ion-Mediated Gelation of Thermo-Responsive Cellulose Nanofibril/Poly(N-Isopropylacrylamide) Hybrid Hydrogels with Tunable De-Swelling Kinetics. Macromolecular Materials and Engineering 2024. https://doi.org/10.1002/mame.202300457.
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Ball, L. E.; Garbonova, G.; Pfukwa, R.; Klumperman, B. Synthesis of Thermoresponsive PNIPAm-b-PVP-b-PNIPAm Hydrogels via Aqueous RAFT Polymerization. Polymer Chemistry 2023.
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Dreyer, R.; Pfukwa, R.; Barth, S.; Hunter, R.; Klumperman, B. The Evolution of SNAP-Tag Labels. Biomacromolecules 2022.
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Ball, L. E.; Pfukwa, R.; Siqueira, R. P.; Mosqueira, V. C. F.; Klumperman, B. PLA-b-SMA as an Amphiphilic Diblock Copolymer for Encapsulation of Lipophilic Cargo. Macromolecular Chemistry and Physics 2022.
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Hutchinson, R. A.; Klumperman, B.; Russell, G. T.; Van Herk, A. M. The Contributions of Prof. Kenneth F. O’Driscoll to Radical Copolymerization Kinetics. Canadian Journal of Chemical Engineering 2022, 100 (4), 680–688. https://doi.org/10.1002/cjce.24137.
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Fang, H.; Sha, Y.; Yang, L.; Jiang, J.; Yin, L.; Li, J.; Li, B.; Klumperman, B.; Zhong, Z.; Meng, F. Macrophage-Targeted Hydroxychloroquine Nanotherapeutics for Rheumatoid Arthritis Therapy. ACS Applied Materials and Interfaces 2022, 14 (7), 8824–8837.
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Giliomee, J.; du Toit, L. C.; Klumperman, B.; Choonara, Y. E. Investigation of the 3D Printability of Covalently Cross-Linked Polypeptide-Based Hydrogels. ACS Omega 2022, 7 (9), 7556–7571. https://doi.org/10.1021/acsomega.1c05873.
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Carter, J. G.; Pfukwa, R.; Riley, L.; Tucker, J. H. R.; Rodger, A.; Dafforn, T. R.; Klumperman, B. Linear Dichroism Activity of Chiral Poly(p-Aryltriazole) Foldamers. ACS Omega 2021. https://doi.org/10.1021/acsomega.1c06139.
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Jharimune, S.; Pfukwa, R.; Chen, Z.; Anderson, J.; Klumperman, B.; Rioux, R. M. Chemical Identity of Poly(N-Vinylpyrrolidone) End Groups Impact Shape Evolution During the Synthesis of Ag Nanostructures. J. Am. Chem. Soc. 2021, 143 (1), 184–195. https://doi.org/10.1021/jacs.0c08528.
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Ball, L. E.; Riley, L. J.; Hadasha, W.; Pfukwa, R.; Smith, C. J. I.; Dafforn, T. R.; Klumperman, Bert. Influence of DIBMA Polymer Length on Lipid Nanodisc Formation and Membrane Protein Extraction. Biomacromolecules 2021, 22 (2), 763–772. https://doi.org/10.1021/acs.biomac.0c01538.
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Xia, Y.; Wei, J.; Zhao, S.; Guo, B.; Meng, F.; Klumperman, B.; Zhong, Zhiyuan. Systemic Administration of Polymersomal Oncolytic Peptide LTX-315 Combining with CpG Adjuvant and Anti-PD-1 Antibody Boosts Immunotherapy of Melanoma. J. Controlled Release 2021, 336 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 262–273. https://doi.org/10.1016/j.jconrel.2021.06.032.
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Giliomee, J.; du Toit, L. C.; Kumar, P.; Klumperman, B.; Choonara, Y. E. Evaluation of Composition Effects on the Physicochemical and Biological Properties of Polypeptide-Based Hydrogels for Potential Application in Wound Healing. Polymers (Basel, Switz.) 2021, 13 (11), 1828. https://doi.org/10.3390/polym13111828.
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Lakay, E.; Hermans, S.; Koch, K.; Klumperman, Bert. The Efficient Recovery of Au(III) Ions from Acidic Solutions by a Novel Scavenger Based on Functionalized Poly(Styrene-Co-Maleimide) Nanoparticles. Chem. Eng. J. (Amsterdam, Neth.) 2021, 414 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 128761. https://doi.org/10.1016/j.cej.2021.128761.
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Grime, R. L.; Logan, R. T.; Nestorow, S. A.; Sridhar, P.; Edwards, P. C.; Tate, C. G.; Klumperman, B.; Dafforn, T. R.; Poyner, D. R.; Reeves, P. J.; Wheatley, Mark. Differences in SMA-like Polymer Architecture Dictate the Conformational Changes Exhibited by the Membrane Protein Rhodopsin Encapsulated in Lipid Nano-Particles. Nanoscale 2021, 13 (31), 13519–13528. https://doi.org/10.1039/d1nr02419a.
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Klumperman, B. Introduction to Reversible Deactivation Radical Polymerization. In Reversible Deactivation Radical Polymerization: Synthesis and Applications of Functional Polymers; 2020; pp 1–13.
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Barnard, E.; Pfukwa, R.; Maiz, J.; Muller, A. J.; Klumperman, Bert. Synthesis, Structure, and Crystallization Behavior of Amphiphilic Heteroarm Molecular Brushes with Crystallizable Poly(Ethylene Oxide) and n-Alkyl Side Chains. Macromolecules (Washington, DC, U. S.) 2020, 53 (5), 1585–1595. https://doi.org/10.1021/acs.macromol.9b02473.
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Klumperman, B.; Heuts, J. P. A. The Solution Copolymerization of Styrene and Maleic Anhydride in a Continuous Stirred Tank Reactor and Its Theoretical Modelling. Polymer 2020, 202 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 122730. https://doi.org/10.1016/j.polymer.2020.122730.
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Cunningham, R. D.; Kopf, A. H.; Elenbaas, B. O. W.; Staal, B. B. P.; Pfukwa, R.; Killian, J. A.; Klumperman, Bert. Iterative RAFT-Mediated Copolymerization of Styrene and Maleic Anhydride toward Sequence- and Length-Controlled Copolymers and Their Applications for Solubilizing Lipid Membranes. Biomacromolecules 2020, 21 (8), 3287–3300. https://doi.org/10.1021/acs.biomac.0c00736.
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Fortuin, L.; Leshabane, M.; Pfukwa, R.; Coertzen, D.; Birkholtz, L.-M.; Klumperman, Bert. Facile Route to Targeted, Biodegradable Polymeric Prodrugs for the Delivery of Combination Therapy for Malaria. ACS Biomater. Sci. Eng. 2020, 6 (11), 6217–6227. https://doi.org/10.1021/acsbiomaterials.0c01234.
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Jokonya, S.; Langlais, M.; Leshabane, M.; Reader, P. W.; Vosloo, J. A.; Pfukwa, R.; Coertzen, D.; Birkholtz, L.-M.; Rautenbach, M.; Klumperman, Bert. Poly(N-Vinylpyrrolidone) Antimalaria Conjugates of Membrane-Disruptive Peptides. Biomacromolecules 2020, 21 (12), 5053–5066. https://doi.org/10.1021/acs.biomac.0c01202.
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Cloete, W. J.; Hayward, S.; Swart, P.; Klumperman, Bert. Degradation of Proteins and Starch by Combined Immobilization of Protease, α-Amylase and β-Galactosidase on a Single Electrospun Nanofibrous Membrane. Molecules 2019, 24 (3), 508/1-508/9. https://doi.org/10.3390/molecules24030508.
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Heyns, I. M.; Pfukwa, R.; Bertossi, L.; Ball, L. E.; Kelland, M. A.; Klumperman, Bert. Thermoresponsive Behavior of Poly(3-Methylene-2-Pyrrolidone) Derivatives. Eur. Polym. J. 2019, 112 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 714–721. https://doi.org/10.1016/j.eurpolymj.2018.10.040.
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Overduin, M.; Klumperman, Bert. Advancing Membrane Biology with Poly(Styrene-Co-Maleic Acid)-Based Native Nanodiscs. Eur. Polym. J. 2019, 110 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 63–68. https://doi.org/10.1016/j.eurpolymj.2018.11.015.
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Kargaard, A.; Sluijter, J. P. G.; Klumperman, Bert. Polymeric SiRNA Gene Delivery - Transfection Efficiency versus Cytotoxicity. J. Controlled Release 2019, 316 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 263–291. https://doi.org/10.1016/j.jconrel.2019.10.046.
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Phiri, M. M.; Hadasha, W.; Pfukwa, R.; Klumperman, Bert. Synthesis and Characterization of Liquid Molecular Brush Binder for Coating Applications. Eur. Polym. J. 2018, 102 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 178–186. https://doi.org/10.1016/j.eurpolymj.2018.03.023.
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Mbizana, S.; Hlalele, L.; Pfukwa, R.; Du Toit, A.; Lumkwana, D.; Loos, B.; Klumperman, Bert. Synthesis and Cell Interaction of Statistical L-Arginine-Glycine-L-Aspartic Acid Terpolypeptides. Biomacromolecules 2018, 19 (7), 3058–3066. https://doi.org/10.1021/acs.biomac.8b00620.
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Zhang, Q.; Heyns, I. M.; Pfukwa, R.; Klumperman, B.; Kelland, M. A. Improving the Kinetic Hydrate Inhibition Performance of 3-Methylene-2-Pyrrolidone Polymers by N-Alkylation, Ring Expansion, and Copolymerization. Energy Fuels 2018, 32 (12), 12337–12344. https://doi.org/10.1021/acs.energyfuels.8b03103.
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Hall, S. C. L.; Tognoloni, C.; Price, G. J.; Klumperman, B.; Edler, K. J.; Dafforn, T. R.; Arnold, Thomas. Influence of Poly(Styrene-Co-Maleic Acid) Copolymer Structure on the Properties and Self-Assembly of SMALP Nanodiscs. Biomacromolecules 2018, 19 (3), 761–772. https://doi.org/10.1021/acs.biomac.7b01539.
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Kemp, R.; Klumperman, B.; Gule, N. Prudence. Novel Core-Sheath Antimicrobial Nanofibrous Mats. J. Appl. Polym. Sci. 2018, 135 (22), n/a. https://doi.org/10.1002/app.46303.
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Kriel, J.; Muller-Nedebock, K.; Maarman, G.; Mbizana, S.; Ojuka, E.; Klumperman, B.; Loos, Ben. Coordinated Autophagy Modulation Overcomes Glioblastoma Chemoresistance through Disruption of Mitochondrial Bioenergetics. Sci. Rep. 2018, 8 (1), 1–13. https://doi.org/10.1038/s41598-018-28590-9.
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Klumperman, L.; Pfukwa, R.; Heyns, I. Marie. Synthesis of 3-Methylene-2-Pyrrolidone Based Polymers., February 22, 2017.
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Weideman, I.; Pfukwa, R.; Klumperman, Bert. Phosphazene Base Promoted Anionic Polymerization of N-Butyraldehyde. Eur. Polym. J. 2017, 93 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 97–102. https://doi.org/10.1016/j.eurpolymj.2017.05.034.
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Hlalele, L.; Pfukwa, R.; Klumperman, Bert. Simulation Studies of the Discrete Semi-Batch RAFT-Mediated Polymerization of Styrene Using a RAFT Agent with Relatively Poor Leaving Group. Eur. Polym. J. 2017, 95 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 596–605. https://doi.org/10.1016/j.eurpolymj.2017.08.053.
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Cloete, W. J.; Klumperman, B.; Cloete, T. Eugene. Increased Functionality Through Surface Grafting: Polymeric Surfaces. Curr. Org. Chem. 2017, 21 (24), 2455–2465. https://doi.org/10.2174/1385272821666170620112440.
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Abrahamsen, E.; Heyns, I. M.; von Solms, N.; Pfukwa, R.; Klumperman, B.; Kelland, M. A. First Study of Poly(3-Methylene-2-Pyrrolidone) as a Kinetic Hydrate Inhibitor. Energy Fuels 2017, 31 (12), 13572–13577. https://doi.org/10.1021/acs.energyfuels.7b03006.
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Heyns, I. M.; Pfukwa, R.; Klumperman, Bert. Synthesis, Characterization, and Evaluation of Cytotoxicity of Poly(3-Methylene-2-Pyrrolidone). Biomacromolecules 2016, 17 (5), 1795–1800. https://doi.org/10.1021/acs.biomac.6b00210.
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Giliomee, J.; Pfukwa, R.; Gule, N. P.; Klumperman, Bert. Smart Block Copolymers of PVP and an Alkylated PVP Derivative: Synthesis, Characterization, Thermoresponsive Behaviour and Self-Assembly. Polym. Chem. 2016, 7 (5), 1138–1146. https://doi.org/10.1039/C5PY01609F.
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Reader, Paul. W.; Pfukwa, R.; Jokonya, S.; Arnott, G. E.; Klumperman, Bert. Synthesis of α,ω-Heterotelechelic PVP for Bioconjugation, via a One-Pot Orthogonal End-Group Modification Procedure. Polym. Chem. 2016, 7 (42), 6450–6456. https://doi.org/10.1039/C6PY01296E.
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Rowan, S. J.; Barner-Kowollik, C.; Klumperman, B.; Gaspard, P.; Grubbs, R. B.; Hillmyer, M. A.; Hutchings, L. R.; Mahanthappa, M. K.; O’Reilly, R. K.; Ouchi, M.; Sawamoto, M.; Lodge, T. P. Discussion on “Aperiodic Copolymers”. ACS Macro Lett. 2016, 5 (1), 1–3. https://doi.org/10.1021/acsmacrolett.5b00758.
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Gule, N. P.; Begum, N. M.; Klumperman, Bert. Advances in Biofouling Mitigation: A Review. Crit. Rev. Environ. Sci. Technol. 2016, 46 (6), 535–555. https://doi.org/10.1080/10643389.2015.1114444.
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Swanepoel, A.; du Preez, I.; Mahlangu, T.; Chetty, A.; Klumperman, B. Development of Bioconjugated Dye-Doped Poly(Styrene-Co-Maleimide) Nanoparticles as a New Bioprobe. J. Mater. Chem. B 2015, 3 (13), 2635–2640. https://doi.org/10.1039/C4TB01520G.
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Du Prez, F.; Hoogenboom, R.; Klumperman, B.; Meier, M.; Monteiro, M.; Muller, A.; Vancso, Julius. Fifty Years of Polymer Science. Eur. Polym. J. 2015, 65 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 3. https://doi.org/10.1016/j.eurpolymj.2015.02.017.
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van Wijk, J.; Salari, J. W. O.; Meuldijk, J.; Klumperman, Bert. Determination of the Shell Growth Direction during the Formation of Silica Microcapsules by Confocal Fluorescence Microscopy. J. Mater. Chem. B 2015, 3 (39), 7745–7751. https://doi.org/10.1039/C5TB01232E.
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Vermonden, T.; Klumperman, Bert. The Past, Present and Future of Hydrogels. Eur. Polym. J. 2015, 72 (Copyright (C) 2021 American Chemical Society (ACS). All Rights Reserved.), 341–343. https://doi.org/10.1016/j.eurpolymj.2015.08.032.
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Ilchev, A.; Pfukwa, R.; Hlalele, L.; Smit, M.; Klumperman, Bert. Improved Control through a Semi-Batch Process in RAFT-Mediated Polymerization Utilizing Relatively Poor Leaving Groups. Polym. Chem. 2015, 6 (46), 7945–7948. https://doi.org/10.1039/C5PY01293G.
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Klumperman, Bert. The Rationale behind Sequence-Controlled Maleimide Copolymers. ACS Symp. Ser. 2014, 1170 (Sequence-Controlled Polymers: Synthesis, Self-Assembly, and Properties), 213–221. https://doi.org/10.1021/bk-2014-1170.ch014.
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Klumperman, Bert. Living Radical Polymerization. In Encycl. Polym. Sci. Technol. (4th Ed.); John Wiley & Sons, Inc., 2014; Vol. 7, pp 648–673.