Prof Jannie Hofmeyr


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Field of research

  • Biochemistry
  • Systems Biology
  • Biocomplexity


Jannie obtained his Ph.D. in Biochemistry in 1986 at the University of Stellenbosch and has been a member of the Biochemistry department since 1975. His main research interest has been the control and regulation of cellular processes using theoretical, computer modelling and experimental approaches. He has made numerous fundamental contributions to the development of metabolic control analysis and computational cell biology, and with Athel Cornish-Bowden developed both co-response analysis and supply-demand analysis as a basis for understanding metabolic regulation. Presently, he seeks ways of expressing formally the functional organisation of the cell in terms of a theory of molecular self-fabrication. This interest has led him to a broader study of complex systems, not only of biological systems, but also of ecological and sociological systems. With the philosopher of complexity Paul Cilliers he established in 2009 the Centre for Studies of Complexity at Stellenbosch, now part of the CST.