Prof. Jannie Hofmeyr

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Field of research

  • Biochemistry
  • Systems Biology
  • Biocomplexity
  • Code Biology
  • Relational Biology


Jannie obtained his Ph.D. in Biochemistry in 1986 at the University of Stellenbosch and has been a member of the Biochemistry department since 1975. His main research interest has been the control and regulation of cellular processes using theoretical, computer modelling and experimental approaches. He has made numerous fundamental contributions to the development of metabolic control analysis and computational cell biology, and with Athel Cornish-Bowden developed both co-response analysis and supply-demand analysis as a basis for understanding metabolic regulation. Presently, he seeks ways of expressing formally the functional organisation of the cell in terms of a theory of molecular self-fabrication. This interest has led him to a broader study of complex systems, not only of biological systems, but also of ecological and sociological systems. With the philosopher of complexity Paul Cilliers he established in 2009 the Centre for Studies of Complexity at Stellenbosch, now part of the CST.


  • Palm, D.C., Rohwer, J.M. & Hofmeyr, J.-H.S. (2013) Regulation of glycogen synthase from mammalian skeletal muscle — a unifying view of allosteric and covalent regulation, FEBS J. 280, 2–27.
  • Pillay, C.S., Hofmeyr, J.-H.S., Mashamaite, L.N. & Rohwer, J.M. (2013) From Top-Down to Bottom-Up: Computational Modeling Approaches for Cellular Redoxin Networks, Antioxidants & Redox Signalling, 18(16), 2075–2086.
  • Cilliers, F.P., Biggs, H.C., Blignaut, S., Choles, A.G., Hofmeyr, J.-H.S., Jewitt, G.P.W. & Roux, D.J. (2013) Complexity, modeling and natural resource management, Ecol. Soc. 18(3), Article 1.
  • Hofmeyr, J.-H.S., Gqwaka, O.P.C. & Rohwer, J.M. (2013) A generic rate equation for catalysed, template-directed polymerisation, FEBS Lett. 587 (17), 2868–2875.
  • Kühn, S. & Hofmeyr, J.-H.S. (2014) Is the histone code an organic code? Biosemiotics, 7(2), 203–222.
  • Palm, D.C., & Rohwer, J.M. & Hofmeyr, J.-H.S. (2014) Incorporating covalent and allosteric effects into rate equations: the case of muscle glycogen synthase. Biochem. J. 462, 525–537.
  • Loos, B., du Toit, A. & and Hofmeyr, J.-H.S. (2014) Defining and measuring autophagosome flux—concept and reality, Autophagy 10 (11), 2087–2096.
  • Carl D. Christensen, Jan-Hendrik S. Hofmeyr & Johann M. Rohwer (2015) Tracing regulatory routes in metabolism using generalised supply-demand analysis. BMC Systems Biology 9:89.


Chapters in Books

  • Wolkenhauer, O. and Hofmeyr, J.-H.S. (2013) Interdisciplinarity as both Necessity and Hurdle for Progress in the Life Sciences, in New Challenges to Philosophy of Science (Andersen, H., Dieks, D., Gonzalez, W.J., Uebel, Th., Wheeler, G., eds.), Springer, pp. 225–235.
  • Loos, B., Hofmeyr, J.-H.S., Müller-Nedebock, K., Boonzaaier, L. and Kinnear, C. (2014) Autophagic flux, fusion dynamics and cell death, in Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Vol.3—Mitophagy (Hayat, E., ed.), Elsevier, pp. 39–56.
  • Du Toit, A., Hofmeyr, J.-H.S., Loos, B. (2017) Methods for Measuring Autophagosome Flux—Impact and Relevance, in Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Vol.11 (Hayat, E., ed.), Elsevier, pp. 91–104.
  • Hofmeyr, J.-H.S. (2017) Exploring the metabolic marketplace through the lens of systems biology, in Philosophy of Systems Biology—Perspectives from Scientists and Philosophers (Green, S., ed.), Springer International Publishing, pp. 117–124.
  • Hofmeyr, J.-H.S. (2017) Basic Biological Autonomy, in Handbook of Anticipation (Poli, R., ed.), Springer (