The transformations required to achieve the Sustainable Development Goals across the African continent demand new ways of mobilising, weaving together, and applying knowledge. Research, policymaking, planning, and action must be effectively inter-linked to address complex sustainability challenges and the different needs and interests of societal actors. Transdisciplinarity (TD) – the co-production of knowledge across disciplines and with non-academic actors – offers a promising, holistic approach to foster such transformations.