I have been involved in projects utilising “omics” technologies to 1) identify genetic variants that predispose individuals to cardiovascular disease (CVD), hypertension and TB; 2) determine the host transcriptional regulatory networks activated upon detrimental or pathogenic stimuli; 3) explore the role of epigenetic modifications such as DNA methylation and chromatin remodelling in disease phenotypes. Other scientific interests and research topics include biomarker discovery, bioinformatics, and the development of genomic resources in South Africa, and it’s understudied yet extremely diverse populations.