Advanced separations

Research Fields

Analytical chemistry, chromatography, multidimensional separations, electrophoresis, mass spectrometry, ion mobility spectrometry

Research Highlights

  • Comprehensive multidimensional LC method development and applications
  • Comprehensive multidimensional GC separations
  • Hyphenation to advanced MS and ion mobility spectrometry

Research Summary

The research group focuses on new developments in the field of separation science. Both fundamental studies aimed at improving current technology and applications research are performed in the group. Areas of particular interest include the method optimisation in comprehensive two-dimensional liquid chromatography, multidimensional gas- and liquid chromatographic separations hyphenated to high resolution mass spectrometry, capillary electrophoresis, sample preparation and ion mobility spectrometry. Applications focus mainly on the analysis of volatile and non-volatile constituents of South African natural products such as indigenous teas, with particular emphasis on the analysis of wine and grapes.

Applications of Research

  • Analysis of indigenous teas honeybush and rooibos
  • Detailed chemical analysis of grapes and wine
  • Natural product analysis



MDMO – application for multidimensional method optimisation.

Information Sheet

MATLAB app version (if you have MATLAB)

Web-based installer 



André de Villiers

Professor of Analytical Chemistry
+27 21 808 3351