Wesley de Villiers started playing the recorder at age 6 in the church orchestra and at age 10, started learning the organ and piano. He attended Wynberg High where he took music as a subject. In 2012, he enrolled as a student of the Certificate Programme, where he was recipient of the Karin Maritz Music Award. In 2014, he attended the satellite campus at the Youngsfield Army base, where he studied music theory under Cheryl George and continued horn studies with Sean Kierman, completing his Grade 7 Unisa theory exam and Grade 8 Horn exam with merit.
He has been an active player in a number of ensembles including the South African National Youth Wind and Symphonic Orchestras, South African National Defence Force Army Band, Stellenbosch University Medical Orchestra, UWC Wind Orchestra, UWC Brass Quintet and the Cape Town Orchestra.
In 2015 he started tutoring some of the students enrolled in the Certificate Programme and later took over the beginner theory classes from Cheryl George. Since 2019 he has been appointed as lecturer in Music Theory, History and Analysis. During the time teaching and tutoring in the programme he obtained a Diploma in Music Theory, Diploma in Music Performance (ATCL), Diploma in Music Performance (DipAbrsm) and Licentiate in Music Performance (LTCL).